Utilizing temperature-sensitive association of Pluronic F-127 with lipid bilayers to control liposome–cell adhesion
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چکیده
منابع مشابه
Pluronic® F-127 and Pluronic Lecithin Organogel (PLO): main features and their applications in topical and transdermal administration of drugs.
Topical drug treatment aims at providing high concentrations of drugs at the site of application so as to avoid adverse systemic effects associated with oral administration. Smart polymers, or stimuli-responsive polymers, are able to respond to a stimulus by showing physical or chemical changes in their behaviour as, for example, the delivery of the drug carried by them. The thermo-responsive n...
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The present study investigated the release profiles of insulin from Pluronic F-127 (PF-127) gel containing unsaturated fatty acids such as oleic acid (18:1), eicosapentaenoic acid (20:5) or docosahexaenoic acid (22:6) and the hypoglycemic effect of insulin following the buccal administration of the gel formulations in normal rats. Insulin release from the gels decreased in the presence of unsat...
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Dental-derived mesenchymal stem cells (MSCs) provide an advantageous therapeutic option for tissue engineering due to their high accessibility and bioavailability. However, delivering MSCs to defect sites while maintaining a high MSC survival rate is still a critical challenge in MSC-mediated tissue regeneration. Here, we tested the osteogenic and adipogenic differentiation capacity of dental p...
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It is, sometimes, desirable to maintain a constant plasma drug concentration within the therapeutically effective concentration range. The use of high viscosity hydromiscible vehicles such as hydrophilic gels, is one of various approaches for controlled drug delivery, and represents an important area of pharmaceutical research and development. Of these systems, Pluronic F-127 (PF-127) provides ...
متن کاملContactless detection of bending sensitive bilayers utilizing higher harmonics
The study concerns a novel contactless sensor system based on a multifunctional magnetostrictive bilayer material. The permeability of the bilayer ribbons is sensitive either to bending or temperature. The higher order harmonics which are generated by the bilayer in response to a magnetic interrogation field are detected. Their amplitudes depend on the bilayer’s permeability, hence on the quant...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2002
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(01)00431-x